The paired box encodes a second DNA-binding domain in the paired homeo domain protein.

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The paired box encodes a second DNA-binding domain in the paired homeo domain protein.

The homeo box, which encodes the DNA-binding homeo domain, is a DNA sequence motif present in several Drosophila developmental genes; it has been used to identify many homologous genes involved in mammalian development. The paired box is another conserved sequence motif, first identified in the paired (prd) and gooseberry (gsb) Drosophila homeo domain genes. It encodes a 128-amino-acid domain, ...

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A homeo-paired domain-binding motif directs Myf5 expression in progenitor cells of limb muscle.

Recruitment of multipotent mesodermal cells to the myogenic lineage is mediated by the transcription factor Myf5, the first of the myogenic regulatory factors to be expressed in most sites of myogenesis in the mouse embryo. Among numerous elements controlling the spatiotemporal pattern of Myf5 expression, the -58/-56 kb distal Myf5 enhancer directs expression in myogenic progenitor cells in lim...

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Crystal structure of paired domain-DNA complex

This thesis describes the determination of a paired domainDNA complex crystal structure (involving the paired domain of the Drosophila Prd protein), and discusses the structural basis of DNA binding specificity of the paired domain and the structural basis of Pax developmental mutations. It also describes the cocrystallization of the human PAX6 paired domain-DNA complex. Chapter 1 provides an i...

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An alternative splicing event in the Pax-3 paired domain identifies the linker region as a key determinant of paired domain DNA-binding activity.

We have identified alternatively spliced isoforms of murine Pax-3 and Pax-7 which differ by the presence or absence of a single glutamine residue in a linker region which separates two distinct DNA-binding subdomains within the paired domain. By reverse transcription-PCR, these isoforms of Pax-3 and Pax-7 (Q+ and Q-) were detected at similar levels through multiple developmental stages in the e...

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ژورنال

عنوان ژورنال: Genes & Development

سال: 1991

ISSN: 0890-9369

DOI: 10.1101/gad.5.4.594